Acidgone® - Natural Alternative for Aciphex (rabeprazole

generic name for Aciphex) visit: http://acidgone.com/

AcipHex (rabeprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

AcipHex is used short-term to treat symptoms of gastroesophageal reflux disease (GERD) in adults and children who are at least 1 year old.

AcipHex is used only in adults to treat conditions involving excessive stomach acid, such as Zollinger-Ellison syndrome. Rabeprazole is also used in adults to promote healing of duodenal ulcers or erosive esophagitis (damage to your esophagus caused by stomach acid).

AcipHex may also be given with an antibiotic to prevent duodenal ulcer caused by infection with Helicobacter pylori (H. pylori).

This medicine is not for immediate relief of heartburn symptoms.

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Aciphex Side Effects

Common side effects of Aciphex include: atrophic gastritis. See below for a comprehensive list of adverse effects.

In addition to its needed effects, some unwanted effects may be caused by rabeprazole (the active ingredient contained in Aciphex). In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking rabeprazole:

Less common:

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • cough or hoarseness
  • dark urine
  • dry mouth
  • fever or chills
  • general tiredness and weakness
  • light-colored stools
  • lower back or side pain
  • nausea and vomiting
  • painful or difficult urination
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss
  • yellow eyes and skin

Rare:

  • Bloody urine
  • continuing ulcers or sores in the mouth
  • convulsions (seizures)
  • difficulty with breathing
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence not known:

  • Back, leg, or stomach pains
  • bleeding gums
  • blood in the urine or stools
  • bloody, black, or tarry stools
  • change in consciousness
  • clay-colored stools
  • cloudy urine
  • confusion about identity, place, person, and time
  • continuing nausea or vomiting
  • difficulty with swallowing
  • dizziness
  • drowsiness
  • fast heartbeat
  • general body swelling
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination or amount of urine
  • headache
  • high fever
  • hives
  • holding false beliefs that cannot be changed by fact
  • increase in the frequency of seizures
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • loss of consciousness
  • mood or mental changes
  • muscle cramps
  • muscle pain or stiffness
  • muscle spasms (tetany) or twitching
  • no blood pressure
  • no breathing
  • no pulse
  • nosebleeds
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seeing, hearing, or feeling things that are not there
  • seizures
  • skin blisters
  • skin rash
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tightness in the chest
  • trembling
  • unpleasant breath odor
  • unusual excitement, nervousness, or restlessness
  • vomiting of blood

Severity: Minor

Some of the side effects that can occur with rabeprazole may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

  • Bad, unusual, or unpleasant (after) taste
  • change in taste

Less common

  • Body aches or pain
  • congestion
  • constipation
  • diarrhea
  • excess air or gas in the stomach or intestines
  • feeling weak
  • full feeling
  • heartburn
  • numbness, tingling, pain, or weakness in the hands or feet
  • pain
  • passing gas
  • runny nose
  • sleepiness
  • swollen joints
  • tender, swollen glands in the neck
  • voice changes

Incidence not known:

  • Blistering, peeling, or loosening of the skin
  • red, irritated eyes
  • red skin lesions, often with a purple center

News for Aciphex(rabeprazole-generic name for Aciphex),

  • Clues to How Popular Heartburn Drug Might Harm Arteries, May 10, 2016

TUESDAY May 10, 2016 -- A popular over-the-counter heartburn medication accelerated aging of blood vessel cells in lab tests, raising red flags about its long-term effect on heart health, researchers say.

Faster aging of blood vessel cells exposed to the antacid Nexium(esomeprazole) might potentially hinder the tasks these cells perform to prevent heart attack and stroke, the new study suggests.

These lab results could explain why other studies have shown increased risk of heart disease in people who use proton pump inhibitors (PPIs) -- the class of heartburn medication that includes Nexium, said study senior author Dr. John Cooke.

"Our finding that the lining of blood vessels is impaired by proton pump inhibitors is a unifying mechanism for the reports that PPI users are at increased risk for heart attack, stroke and renal failure," said Cooke, chair of cardiovascular sciences at the Houston Methodist Research Institute.

However, many people aren't using PPIs in accordance with FDA guidelines, which in Nexium's case would limit them to a four-week course of treatment three times a year, Cooke said.

For more information, visit: https://www.nlm.nih.gov/medlineplus/news/fullstory_158754.html

  • 1 in 4 Hospitalized Newborns Gets Heartburn Drugs, Despite Risks, Apr.27, 2016

WEDNESDAY April 27, 2016, 2016 -- Despite reported risks, nearly one in four infants in neonatal intensive care units (NICUs) are given stomach acid-suppressing drugs, researchers report.

A number of studies have linked the use of stomach acid-suppressing drugs in hospitalized high-risk infants with infections, necrotizing enterocolitis (a serious disease where intestinal tissue begins to die off) and increased risk of death, the researchers said.

These drugs include histamine-2 receptor antagonists such as ranitidine(Zantac),and proton pump inhibitors such as esomeprazole(Nexium).

But, "there's actually little evidence that acid suppression helps in the NICU at all," Slaughter said in a hospital news release.

For more information, visit: https://consumer.healthday.com/pregnancy-information-29/premature-birth-news-774/quarter-of-newborns-given-stomach-acid-suppressing-drugs-study-710355.html

  • Doctors Often Overestimate Promise of Newly Approved Drugs, Apr.12, 2016

TUESDAY April 12, 2016, 2016 -- Use of the word "breakthrough" in the U.S.Food and Drug Administration expedited approval process could mislead doctors about the new drugs' actual benefits, researchers warn.

The U.S. Congress in 2012 gave FDA the power to designate a drug as a "breakthrough therapy" if preliminary clinical evidence suggests an advantage over existing medications.

But a survey of nearly 700 doctors revealed that many tended to misinterpret "breakthrough." Doctors often believed the drugs were supported by stronger evidence than the law requires to achieve that designation, said lead author Dr. Aaron Kesselheim. He is a faculty member at Brigham and Women's Hospital in Boston.

"When people hear 'breakthrough,' it gives them an inappropriately elevated sense of what the drug might do," Kesselheim said. "It may give physicians false reassurance about the outcomes they might expect to receive when they prescribe it."

In the survey, nine out of 10 doctors chose one hypothetical drug over another identical one solely based on the "breakthrough" designation, even though both were taken on the same schedule, had similar side effects, and were equally covered by the patient’s insurance.

In addition, 52 percent incorrectly believed that strong evidence from randomized trials is needed to earn the breakthrough designation, the researchers found.

"They thought when a drug is labeled as a breakthrough therapy it actually is a breakthrough, and that's not necessarily the case," Kesselheim said. "Many drugs labeled as breakthrough therapies are not true breakthroughs, because they don't provide substantially advanced
treatment over what's already available."

The results were published April 12 in the Journal of the American Medical Association.

Brawley also said he is "convinced there are still some doctors who still tend to think the new drugs are better than the old drugs."

He noted the case of Prilosec, a heartburn medication made by AstraZeneca. When it came time for Prilosec to go generic, AstraZeneca marketed a new heartburn drug called Nexiumfor which it could still charge premium prices.

"They never said that Nexium simply contained the same active ingredient as their old drug Prilosec," Brawley said. "If you'll recall, Nexium became one of the best-selling drugs for years. There are people who are surely prescribing it because it is newer."

For more on "breakthrough" therapies, visit:
U.S.Food and Drug Administration.

  • FDA Alert:Proton Pump Inhibitors (PPIs) - Drug Safety Communication: Clostridium Difficile-Associated Diarrhea (CDAD) Can be Associated With Stomach Acid Drugs, February 8, 2012

 ISSUE: FDA notified the public that the use of stomach acid drugs known as proton pump inhibitors (PPIs) may be associated with an increased risk of Clostridium difficile–associated diarrhea (CDAD). A diagnosis of CDAD should be considered for patients taking PPIs who develop diarrhea that does not improve. The FDA is working with manufacturers to include information about the increased risk of CDAD with use of PPIs in the drug labels.

FDA
is also reviewing the risk of CDAD in users of histamine H2 receptor blockers. H2 receptor blockers are used to treat conditions such as gastroesophageal reflux disease (GERD), stomach and small intestine ulcers, and heartburn.

BACKGROUND Proton pump inhibitors (PPIs) are marketed under various brand and generic drug names as prescription and over-the-counter (OTC) products. They work by reducing the amount of acid in the stomach. Prescription PPIs are used to treat conditions such as gastroesophageal reflux disease (GERD), stomach and small intestine ulcers, and inflammation of the esophagus. Over-the-counter PPIs are used to treat frequent heartburn.

Clostridium difficile (C.difficile) is a bacterium that can cause diarrhea that does not improve. Symptoms include watery stool, abdominal pain, and fever, and patients may go on to develop more serious intestinal conditions. The disease can also be spread in hospitals.  

RECOMMENDATION Patients should immediately contact their healthcare professional and seek care if they take PPIs and develop diarrhea that does not improve. Information for Healthcare Professionals:

  • A diagnosis of CDAD should be considered for PPI users with diarrhea that does not improve.
  • Advise patients to seek immediate care from a healthcare professional if they experience watery stool that does not go away, abdominal pain, and fever while taking PPIs.
  • Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated.

[02/08/2012 - Drug Safety Communication - FDA] 

Are you suffering from Indigestion?

If you've eaten too
much or indulged in a food that's greasy, fatty or spicy, you may have an uncomfortable feeling known as indigestion.

Here are common symptoms, courtesy of the Cleveland Clinic:

  • A burning sensation in the stomach or upper abdomen.
  • Abdominal pain
  • Bloating (full feeling), belching and gas
  • Nausea and vomiting
  • Growling stomach.
  • An acidic taste in the mouth.
  • Occasional diarrhea.
  • Symptoms usually increase in times of stress, and decrease in times of relaxation.

For more details, visit:

http://my.clevelandclinic.org/search/results?q=Is%20it%20Indigestion

http://my.clevelandclinic.org/health/diseases_conditions/hic_Gastritis/hic_Indigestion

 

 

Acidgone® - Natural Alternative for Aciphex (rabeprazole- generic name for Aciphex), visit: http://acidgone.com/

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